The dynamic centromere

Angela Enriquez

doi:10.1007/s10577-025-09779-x

2025-10-16

Angela Enriquez

Yael Nechemia‐Arbely *

DOI：10.1007/s10577-025-09779-x

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摘要

En 中文

着丝粒是基本的染色体结构，确保细胞分裂过程中染色体准确分离。尽管着丝粒在维持基因组稳定性方面具有保守且必不可少的作用，但它们会经历快速进化。着丝粒身份的核心是组蛋白H3变体CENP-A，它是一种表观遗传标记，用于定义和传播活性着丝粒，并对着丝粒功能至关重要。最新证据支持着丝粒DNA序列的快速进化，但也表明CENP-A的沉积和传播具有一定程度的灵活性。着丝粒漂移这一现象近期在人类中被观察到，突显了CENP-A的动态重新定位以及随时间变化的关联表观遗传环境如何维持一种调控平衡，确保着丝粒功能不受位置变化的影响。理解这些过程对于阐明着丝粒动态及其对基因组稳定性和进化的更广泛影响至关重要。

Keyword:

Centromeres

CENP-A

Chromatin

Mitosis

Epigenetics

Evolution

期刊

Chromosome Research

IF:

2.8

论文数:

被引数:

机构

pennsylvania commonwealth system of higher education (pcshe)

学者数:

12.9W

论文数: 11.7W

被引数: 177

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