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The emerging role of NAT10-mediated N4-acetylcytidine modification of RNA in bone diseases: Current frontiers and future challenges
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DOI：10.1016/j.lfs.2026.124582.png)
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Abstract
En 中文
• NAT10 is the principal writer of ac4C on rRNA, tRNA and likely mRNA. • NAT10/ac4C regulates osteogenesis, osteoclastogenesis and cartilage homeostasis. • NAT10 inhibition shows preclinical promise in osteoporosis and osteosarcoma. • mRNA ac4C abundance remains debated; orthogonal detection methods are needed. • Single-cell and spatial epitranscriptomics are key future directions for ac4C in bone.
Keywords:
RNA acetylation
N4-acetylcytidine
NAT10
Epitranscriptomics
Osteoporosis
Osteosarcoma
BMSC differentiation
Remodelin
Acetyl-CoA
Ropinirole
Paliperidone
AG-401
Selinexor
Bortezomib
5-Fluorouracil
Sodium citrate
BMP-2
Journal
IF:
5.1
Papers:
1.7W
Citations:
4.7W
Organization
Cited Papers