The Evolving T Cell Receptor Recognition Code: The Rules Are More Like Guidelines

doi:10.1111/imr.13439

2025-01-13

PRE

George I. Gray

P. Chukwunalu Chukwuma

Bassant Eldaly

W. W. J. Gihan Perera

Chad A. Brambley

Tatiana J. Rosales

Brian M. Baker *

DOI：10.1111/imr.13439

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摘要

En 中文

αβ T细胞受体（TCR）对肽-MHC复合物的识别是适应性免疫的核心，通过平衡特异性和交叉反应性以促进有效的抗原识别。早期结构研究建立了有助于理解和阐释TCR识别及其特征（如肽特异性及MHC限制性）的基本框架。然而，不断增长的TCR结构数据库及基于结构研究的探索持续揭示出对早期研究推导出的普遍假设和简化模型的例外情况。本文探讨了我们对TCR识别的演变认知，阐述了结构及生物物理研究如何持续揭示复杂现象，这些现象挑战了现有范式并拓展了我们关于TCR如何结合并区分肽/MHC复合物的理解。我们讨论了这些发现对基础免疫学、转化免疫学及预测免疫学的意义，包括在解释TCR识别固有的适应性、灵活性及偶发的生物物理“松弛性”特征时所面临的挑战。

Keyword:

COMPLEX CLASS-I

MHC CLASS-II

STRUCTURAL BASIS

CROSS-REACTIVITY

ANTIGEN RECOGNITION

BETA-CHAIN

RESTRICTED RECOGNITION

PROTEIN-STRUCTURE

FINE SPECIFICITY

MELANOMA ANTIGEN

期刊

Immunological Reviews

IF:

8.3

论文数:

3.3K

被引数:

1.8W

机构

Univ Notre Dame

学者数:

576

论文数: 324

被引数: 106

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