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The extent of monocytic myeloid suppressor cells induction determines the host immune response during Mycobacterium avium infection
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DOI：10.1016/j.micinf.2025.105591.png)
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Abstract
En 中文
Mycobacterium avium is a slow-growing non-tuberculous mycobacterium. While its medical importance is increasing, its virulence is only poorly characterized. A highly virulent M. avium strain ATTC25291 (MAA25291) has been shown to cause severe disease in mice by survival and growth in nitric oxide (NO) producing, immune suppressive monocytic-MDSC (M-MDSC). The induction and persistence of MAA25291 in M-MDSC is still unresolved. In the present study, we were interested in the role of M-MDSC in mice infected with MAA25291 at infection doses that led to the manifestation of clinical disease (high dose) or subclinical disease (low dose). Flow cytometry revealed the presence of M-MDSC in both infection groups; however, this infiltration was significantly lower after low dose infection. Histopathology showed lower infiltration of NOS2 expressing cells in spleens and liver correlated with high CD3+ T cell numbers after low dose infection, whereas high dose infection of mice led to T cell losses in the tissues. This study highlights that the infection dose significantly affects M-MDSC induction and their immune regulatory roles. Furthermore, it suggests that the induction and persistence of MAA25291 in M-MDSC relies on the amount of NO production.
Keywords:
mycobacterium
mice infection
MDSC
NOS2
T cells
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