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The feast of prisoners: Confining drugs and inflammatory factors locally in tumors
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DOI：10.1016/j.jconrel.2026.115210.png)
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Abstract
En 中文
• LOCK therapy converts PDT/PTT-induced vascular damage into sustained occlusion to suppress metastasis. • TXA stabilizes microthrombi, inhibits ECM degradation, and prevents premetastatic niche formation. • IR780/TXA TRN@PM enables spatiotemporally controlled delivery, overcoming TXA's short half-life. • LOCK therapy enhances drug retention and remodels immunity by promoting CD8⁺ T cells while reducing M2 macrophages.
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11.5
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1.5W
Citations:
7.4W
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