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The FGFRL1–FASN axis regulates neuroendocrine lineage transdifferentiation by modulating fatty acid synthesis in AR pathway-independent prostate cancer
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DOI：10.1016/j.canlet.2026.218769.png)
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Abstract
En 中文
• Attenuated fatty acid synthesis activity marks neuroendocrine features in ARIPC. • FASN depletion promotes neuroendocrine lineage plasticity in ARIPC. • FGFRL1 regulates FASN-driven lipogenesis and neuroendocrine plasticity in ARIPC. • FGFRL1-FASN axis governs neuroendocrine programs through ONECUT2.
Journal
IF:
10.1
Papers:
1.7W
Citations:
4.3W
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