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The Hippo Signaling Pathway in Development and Cancer
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DOI：10.1016/j.devcel.2010.09.011.png)
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Abstract
En 中文
First discovered in Drosophila, the Hippo signaling pathway is a conserved regulator of organ size. Central to this pathway is a kinase cascade leading from the tumor suppressor Hippo (Mst1 and Mst2 in mammals) to the oncoprotein Yki (YAP and TAZ in mammals), a transcriptional coactivator of target genes involved in cell proliferation and survival. Here, I review recent progress in elucidating the molecular mechanism and physiological function of Hippo signaling in Drosophila and mammals. These studies suggest that the core Hippo kinase cascade integrates multiple upstream inputs, enabling dynamic regulation of tissue homeostasis in animal development and physiology.
Keywords:
YES-ASSOCIATED PROTEIN
TUMOR-SUPPRESSOR PATHWAY
ORGAN SIZE CONTROL
REGULATE CELL-PROLIFERATION
EPITHELIAL-MESENCHYMAL TRANSITION
POLARITY DETERMINANT CRUMBS
MESSENGER-RNA EXPRESSION
SCF-BETA-TRCP
TRANSCRIPTION FACTOR
DOMAIN PROTEIN
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