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The Imageable Genome
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DOI：10.1038/s41467-023-43123-3.png)
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摘要
En 中文
Understanding human disease on a molecular level, and translating this understanding into targeted diagnostics and therapies are central tenets of molecular medicine1. Realizing this doctrine requires an efficient adaptation of molecular discoveries into the clinic. We present an approach to facilitate this process by describing the Imageable Genome, the part of the human genome whose expression can be assessed via molecular imaging. Using a deep learning-based hybrid human-AI pipeline, we bridge individual genes and their relevance in human diseases with specific molecular imaging methods. Cross-referencing the Imageable Genome with RNA-seq data from over 60,000 individuals reveals diagnostic, prognostic and predictive imageable genes for a wide variety of major human diseases. Having both the critical size and focus to be altered in its expression during the development and progression of any human disease, the Imageable Genome will generate new imaging tools that improve the understanding, diagnosis and management of human diseases.
Keyword:
IN-VIVO EVALUATION
MOLECULAR MEDICINE
GENE-EXPRESSION
HUMAN HEART
PET TRACER
CANCER
RADIOTRACER
SEQUENCE
REVEALS
LIGAND
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期刊
IF:
15.7
论文数:
9.3W
被引数:
91.2W
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