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The Impact of Human Papillomavirus Catch-Up Vaccination in Australia: Implications for Introduction of Multiple Age Cohort Vaccination and Postvaccination Data Interpretation

delete2017-09-12
delete34
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OA
AI
M
Mélanie Drolet
J
Jean-François Laprise
J
Julia Brotherton
B
Basil Donovan
C
Christopher K. Fairley
H
Hammad Ali
É
Élodie Bénard
D
Dave Martin
M
Marc Brisson *
DOI:10.1093/infdis/jix476delete
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Abstract

Abstract

En 中文
We used transmission-dynamic modeling to estimate the added effectiveness of vaccinating multiple cohorts of females (12-26 years) in Australia compared with the theoretical introduction of routine-only (12-13 years) vaccination. Our results suggest that vaccinating multiple cohorts produced markedly faster direct/herd effects, and it added benefits that last for 20-70 years. Furthermore, the number needed to vaccinate to prevent 1 anogential warts (AGW) case or cervical cancer (CC) was similar for routine + catch-up (AGW = 9.9, CC = 678) and routine-only vaccination (AGW = 9.9, CC = 677), thus providing similar levels of efficiency per person vaccinated.
Keywords:
anogenital warts
cervical cancers
human papillomavirus
mathematical modeling
vaccination
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Journal of Infectious Diseases cover
Journal of Infectious Diseases
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laval university hospital
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Kirby Institute
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laval university
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