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The intracellular journey of DNA delivered with the protein-based transfection system TFAMoplex and Lipofectamine
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DOI：10.1016/j.ijpharm.2025.125855.png)
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Abstract
En 中文
• High-precision imaging assays are applied to provide detailed insights into intracellular DNA trafficking. • Labeled DNA uptake is quantified with a novel anti-dye-antibody assay. • Colocalization of DNA with barrier-to-autointegration-factor (BAF) is assessed. • Imaging assays are used to study differences between protein-based TFAMoplex transfection systems and Lipofectamine. • TFAMoplex-based transfection mediates strong DNA cell association, high particle uptake and high transfection efficiency.
Keywords:
Non-viral gene delivery
Protein-based transfection
DNA trafficking
Intracellular imaging
Image analysis
Journal
IF:
5.2
Papers:
2.2W
Citations:
6.7W
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