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The joint effect of variants of genes related to dopamine and serotonin action is associated with food intake in children
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DOI：10.1080/1028415X.2026.2665392.png)
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Abstract
En 中文
Obesity is one of the major health issues worldwide. One of the causes for its high prevalence is the exposure to an obesogenic environment, leading to overconsumption of high-palatable food. However, not everyone exposed to an obesogenic environment develops obesity, which means that a genetic background may be involved. Dopamine and serotonin are neurotransmitters intimately involved in hedonic eating, and variants in related genes have been previously associated with food intake. Yet, most of these studies only focus on the individual effect of the variants, which tends to be very little in complex traits like food intake, and fail to capture more complex interactions like gene-gene. In this study, we used partial least squares (PLS) regression to analyze the joint effect of 11 dopamine and/or serotonin-related genetic variants on average daily energy intake of sugar-dense (SDF) and lipid-dense (LDF) foods. The sample comprised 1,074 children from two cohorts, who were observed until the age of six and evaluated at 12 months, three years, and six years of age. In our sample, the explained variance for daily energy intake models ranged from 64.8 to 79.9%, for SDF from 44.0 to 52.4%, and for LDF from 42.7 to 50.3%. Our results demonstrate the contribution of the joint effect of the dopamine and serotonin-related variants on daily energy intake of food. To our knowledge, this is the first study using PLS regression to investigate the influence of the joint effect of genetic variants on complex phenotypes; more studies with this analysis are important for definitive conclusions.
Keywords:
Dopamine
energy intake
genetic variation
obesity
serotonin
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