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The Metabolite indole-3-acetic acid of Bacteroides ovatus ameliorates ovariectomy-induced bone loss by activating AhR and inhibiting oxidative stress
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DOI：10.1016/j.freeradbiomed.2026.07.050.png)
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Abstract
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• Based on metagenomic sequencing data, combined with WGCNA and machine learning, B. ovatus was identified as a potential key gut microbe that alleviates postmenopausal osteoporosis. • Through in vivo experiments and metagenomic sequencing, B. ovatus was verified to attenuate bone loss in OVX mice. • In vivo experiments confirmed that B. ovatus alleviates bone loss in OVX mice by producing IAA. • In vitro assays demonstrated that IAA interacts with AhR, upregulates NQO1 expression, suppresses intracellular ROS production, and consequently inhibits osteoclast differentiation.
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