The Nanomedomics

doi:10.1021/acsnano.3c11154

2024-04-18

PRE

DOI：10.1021/acsnano.3c11154

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摘要

En 中文

Nanomaterials have attractive physicochemical properties. A variety of nanomaterials such as inorganic, lipid, polymers, and protein nanoparticles have been widely developed for nanomedicine via chemical conjugation or physical encapsulation of bioactive molecules. Superior to traditional drugs, nanomedicines offer high biocompatibility, good water solubility, long blood circulation times, and tumor-targeting properties. Capitalizing on this, several nanoformulations have already been clinically approved and many others are currently being studied in clinical trials. Despite their undoubtful success, the molecular mechanism of action of the vast majority of nanomedicines remains poorly understood. To tackle this limitation, herein, this review critically discusses the strategy of applying multiomics analysis to study the mechanism of action of nanomedicines, named nanomedomics, including advantages, applications, and future directions. A comprehensive understanding of the molecular mechanism could provide valuable insight and therefore foster the development and clinical translation of nanomedicines.

Keyword:

nanomedicine

mechanism of action

genomics

transcriptomics

proteomics

metabolomics

multiomics

nanomedomics

drug delivery

regenerative medicine

期刊

ACS Nano

IF:

论文数:

2.6W

被引数:

25.6W

机构

changchun institute of applied chemistry, cas

学者数:

3.4K

论文数: 3.2K

被引数: 10

chinese academy of sciences

学者数:

56.7W

论文数: 45.0W

被引数: 704

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