.png){kind=icon}
返回
The PRIMARY Score
.png){kind=icon}
OA
AI
DOI：10.1097/RLU.0000000000004951.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Purpose: Multiparametric MRI is the current standard for detecting clinically significant prostate cancer (csPCa). However, men with negative or equivocal MRI often undergo unnecessary biopsies due to concerns about false-negative results. The recently proposed Ga-68-PSMA PET/CT-based PRIMARY score exhibited good diagnostic performance for csPCa. This study aimed to externally validate the performance of the PRIMARY score and evaluate its added diagnostic value to MRI triage in detecting csPCa.Patients and Methods: This retrospective cohort study included 431 men who underwent both Ga-68-PSMA PET/CT and MRI before biopsy. Performance was assessed using the area under the receiver operating characteristic curve and the decision curve analysis. The PRIMARY score + MRI was considered positive for either PRIMARY score 3-5 or Prostate Imaging Reporting and Data System (PI-RADS) 4/5.Results: The prevalence of csPCa was 51.7% (223/431). The area under the receiver operating characteristic curve of the 5-level PRIMARY score for csPCa was significantly higher than that of MRI (0.873 vs 0.786, P < 0.001). For the entire group, sensitivity, specificity, positive predictive value, and negative predictive value of the PRIMARY score were 90.6%, 61.1%, 71.4%, and 85.8%, respectively, which outperformed 87.9%, 49.0%, 64.9%, and 79.1% of PI-RADS on MRI. The PRIAMRY score + MRI improved sensitivity (96.0% vs 87.9%, P < 0.001) and negative predictive value (91.5% vs 79.1%, P < 0.001) without compromising specificity and positive predictive value compared with MRI alone. This combined approach avoided 24.6% (106/431) of unnecessary biopsies, while missing 4.0% (9/223) of csPCa cases. The addition of the PRIMARY score in men with PI-RADS 1-3 showed a net benefit, but not in men with PI-RADS 4/5.Conclusions: The PRIMARY score was superior to MRI in detecting csPCa, and its added diagnostic value was in men with negative or equivocal MRI results. The PRIMARY score + MRI improved negative predictive value and sensitivity for csPCa compared with MRI alone. Further prospective trials will validate whether men with clinical suspicion of csPCa but negative PRIMARY score + MRI can safely avoid unnecessary biopsies.
Keyword:
PRIMARY score
PSMA PET/CT
prostate cancer
MRI
diagnosis
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
9.6
论文数:
1.1W
被引数:
6.9K
机构
引用论文
分享收藏Negative Predictive Value of Multiparametric Magnetic Resonance Imaging in the Detection of Clinically Significant Prostate Cancer in the Prostate Imaging Reporting and Data System Era: A Systematic Review and Meta-analysis在前列腺影像报告和数据系统时代，多参数磁共振成像在检测具有临床意义的前列腺癌中的阴性预测价值: 系统回顾和荟萃分析.png)
EUROPEAN UROLOGYOAAI
EUROPEAN UROLOGYIF25.2
OAAI分享收藏PI-RADS Prostate Imaging - Reporting and Data System: 2015, Version 2Pi-rads前列腺成像-报告和数据系统: 2015，版本2EUROPEAN UROLOGYOAAI
EUROPEAN UROLOGYIF25.2
OAAI分享收藏Establishment and prospective validation of an SUVmax cutoff value to discriminate clinically significant prostate cancer from benign prostate diseases in patients with suspected prostate cancer by 68Ga-PSMA PET/CT: a real-world studyTHERANOSTICSOAAI
THERANOSTICSIF13.3
OAAI分享收藏Prostate Imaging Reporting and Data System Version 2.1: 2019 Update of Prostate Imaging Reporting and Data System Version 2前列腺影像报告和数据系统版本2.1: 前列腺影像报告和数据系统版本2的2019更新EUROPEAN UROLOGY
EUROPEAN UROLOGYIF25.2
PREAI
分享收藏
查看更多内容