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The protein epiphany

delete2026-09-25
delete0
PRE
AI
E
E.J. Dodson *
DOI：10.1107/s2059798326008739delete
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摘要

摘要

En 中文
谢尔德里克通过提供优秀的软件来解决一系列晶体结构问题而闻名，这些晶体具有良好的衍射性能且原子数少于200。所使用的技术包括帕特森搜索、直接法相位测定以及最终模型的逐次最小二乘法精修。到20世纪90年代，从大分子中收集原子分辨率数据已成为可能，因此他将逐次最小二乘法精修程序改进以处理这些情况下所需的大量参数。大分子的实验相位可以通过硫等重原子的反常信号计算得到。结构解析软件被改进以利用小的反常差异寻找反常散射体的位置，随后扩展为首先生成和精修相位，然后解释所得的电子密度图。
Keyword:
SHELX software for large molecules
refinement
experimental phasing
model building

期刊

A
Acta Crystallographica Section D
IF:
0
论文数:
33
被引数:
0

机构

U
University of York
学者数:
287
论文数: 147
被引数: 0
引用论文

引用论文

Experimental phasing with SHELXC/D/E: combining chain tracing with density modification
errActa Crystallographica Section D Biological Crystallography
IF0
err2010-03-24
err0
errOAAI
errGeorge M. Sheldrick
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Extending molecular-replacement solutions withSHELXE使用 SHELXE 扩展分子置换解决方案
errActa Crystallographica Section D Biological Crystallography
IF0
err2013-10-18
err0
errOAAI
errAndrea Thorn; George M. Sheldrick
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A short history ofSHELXSHELX 的简短历史
errActa Crystallographica Section A Foundations of Crystallography
IF0
err2007-12-21
err0
errOAAI
errGeorge M. Sheldrick
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A graphics model building and refinement system for macromolecules大分子的图形模型建立和细化系统
errJournal of Applied Crystallography
IF0
err1978-08-01
err0
PREAI
errT. A. Jones
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Refinement of rubredoxin from Desulfovibrio vulgaris at 1.0 Å with and without restraints
errActa Crystallographica Section B Structural Science
IF0
err1992-02-01
err0
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errZ. Dauter; L. C. Sieker; K. S. Wilson
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The Shake-and-Bake structure determination of triclinic lysozyme
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err1998-08-04
err43
errOAAI
errDeacon, AM; Weeks, CM; Miller, R; Ealick, SE
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PROTEIN CRYSTALLOGRAPHY AND ITS NEW REVOLUTION
errTRENDS IN BIOCHEMICAL SCIENCES
IF11
err1986-08-01
err0
PREAI
errDODSON, G
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SnB: crystal structure determination via shake-and-bake
errJournal of Applied Crystallography
IF0
err1994-08-01
err0
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errR. Miller; S. M. Gallo; H. G. Khalak; C. M. Weeks
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ACORN in CCP4 and its applications
errActa Crystallographica Section D Biological Crystallography
IF0
err2002-10-21
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errJia-xing Yao
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Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia
errScience
IF0
err1985-12-20
err0
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errRandall K. Saiki; Stephen Scharf; Fred Faloona; Kary B. Mullis; Glenn T. Horn; Henry A. Erlich; Norman Arnheim
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