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The Role of Periodontitis in the Initiation and Progression of Cognitive Disorders: An Umbrella Review
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DOI：10.1016/j.jebdp.2026.102307.png)
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Abstract
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• Periodontitis is consistently associated with increased risk of cognitive disorders. • Severe periodontitis correlates with stronger neurodegenerative and cognitive outcomes. • Inflammatory and microbial mechanisms likely mediate the link between periodontitis and cognitive disorders. • Future research should employ longitudinal and interventional designs to elucidate the causal mechanisms underlying these findings
Keywords:
Alzheimer’s disease
dementia
periodontitis
inflammation
umbrella review
neurodegeneration
PROSPERO CRD42024608894
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