.png){kind=icon}
.png){kind=icon}
Return
The role of YY1 in promoting cancer immune evasion
.png){kind=icon}
PRE
AI
M
J
R
I
D
隋
DOI：10.1016/j.bbcan.2026.189595.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
The immune system plays a vital role to prevent cancers from occurrence and development. The eventual onset and progression of cancers necessitate the compromise of immune surveillance, and the dysregulation of many key regulators contribute to this process. Understanding the mechanisms and identifying key players regulating immune evasion is crucial for effective anticancer therapies that revive the immune system. As a multifunctional transcription factor, Yin Yang 1 (YY1) is increasingly expressed in various cancers, and can both stimulate oncogenic development and promote immune evasion of cancer cells. In this review, we categorize the YY1-regulated cancer immune evasion into a previously defined framework, including camouflage, coercion, and cytoprotection with a focus on gene expression network in different cancers. We first outline the studies of how YY1 enables cancer cells to avoid immune system recognition. Second, we review the research related to how YY1 attenuates the tumor suppressive functions of immune effector cells. Third, we elaborate YY1-mediated mechanisms to protect cancer cells from cytotoxicity of immune cells. Finally, we discuss the complexity of the YY1-involved regulatory network of cancer immune evasion.
Keywords:
YY1
cancer immune evasion
transcription factor
immune surveillance
gene expression network
Journal
B
IF:
0
Papers:
105
Citations:
0
Organization
No organization information available
Cited Papers