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The transcriptomic immune profiling across the different Ileal Layers Highlights the Relevant Role of Neutrophils and the active involvement of Healthy Mucosa in Human Crohn’s Disease
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DOI：10.1016/j.imlet.2026.107168.png)
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Abstract
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• First comprehensive gene expression profiling across ileal wall layers in CD • Neutrophils enriched in diseased and healthy serosa, key in transmural CD spread • Damaged mucosa shows strongest upregulation of cytokine and chemokine genes • Fcγ receptor and innate immune pathways drive mucosal inflammation in CD • Healthy ileum mirrors immune gradients, suggesting early role in CD pathogenesis
Keywords:
Crohn’s disease
transcriptomic
immunity
neutrophils
surgery
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