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Therapeutic Gfral silencing via antisense oligonucleotides ameliorates cancer-associated cachexia and extends survival in tumor-bearing mice

delete2026-07-27
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OA
AI
H
Hyun Jung Hong
M
Min Hee Lee
M
Minsung Park
J
Jung Tae Kim
J
Jaehun Kim
S
Sang-Hyeon Ju
J
Ju Hee Lee
J
Jong-Woo Sohn
K
Koeun Shong
D
Daiki Setoyama
H
Ho Min Kim
J
Jinkuk Kim *
M
Minho Shong *
DOI：10.1016/j.xcrm.2026.102939delete
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Abstract

Abstract

En 中文
• Central Gfral ASO effectively silences hindbrain GFRAL in cancer cachexia models • Gfral silencing reverses tumor-induced muscle and adipose tissue wasting • ASO therapy offers superior muscle function rescue versus anti-GDF15 antibodies • A single central dose of Gfral ASO significantly extends overall survival
Keywords:
GFRAL
GDF15
antisense oligonucleotides
cancer-associated cachexia
muscle wasting
metabolic dysfunction
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Journal

Cell Reports Medicine cover
Cell Reports Medicine
IF:
10.6
Papers:
2.2K
Citations:
8.9K

Organization

T
thor therapeutics inc.
Scholars:
2
Papers: 1
Citations: 0
K
Kyushu University Hospital
Scholars:
78
Papers: 50
Citations: 750
I
ibs
Scholars:
89
Papers: 24
Citations: 0
C
Chungnam National University
Scholars:
1.5W
Papers: 1.4W
Citations: 1.2W
K
Korea Advanced Institute of Science and Technology
Scholars:
3.2K
Papers: 1.3K
Citations: 254
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