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Therapy-Associated Lineage Plasticity in DIPG Following Combined CDK4/6 Inhibitor, Temozolomide, and Radiation

delete2026-07-30
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PRE
AI
Z
Zilu Huang
T
Tongchao Jiang
M
Milagros M. Suarez Palacios
T
Tommy Ouyang
A
Aalaa Abdallah
L
Long Niu
J
Jinnan Chen
X
Xin Zhai
W
Wenan Qiang
R
Runxin Wu
N
Nitin R. Wadhwani
A
Alicia Lenzen
M
Michael DeCuypere
S
Sandi Lam
A
Aria Hoesley
S
Shi-Yuan Cheng
C
Ching Man Wai
B
Brian Wray
M
Matthew J. Schipma
DOI：10.1016/j.canlet.2026.218771delete
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Abstract

Abstract

En 中文
• DIPG PDOX-derived 3D tumor organoids show positive drug interactions in vitro. • Triple therapy shows survival benefit in two distinct DIPG PDOX models. • Endpoint scRNA-seq reveals therapy-associated lineage plasticity in DIPG. • A radiation-resistance-associated cluster reveals candidate therapeutic targets.

Journal

Cancer Letters cover
Cancer Letters
IF:
10.1
Papers:
1.7W
Citations:
4.3W

Organization

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