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Thermo-sensing mechanisms of splicing control by nuclear stress bodies

delete2026-07-16
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OA
AI
T
Tsuyoshi Ueno
S
Shungo Adachi
I
Ichiro Taniguchi
N
Nobuo N. Noda
K
Kensuke Ninomiya
T
Tetsuro Hirose *
DOI:10.1016/j.molcel.2026.06.034delete
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Abstract

Abstract

En 中文
• CLK1 Ser341 phosphorylation controls its localization to nuclear stress bodies • PP1 and RIOK2 reciprocally regulate CLK1 Ser341 phosphorylation • PPP1R2 acts as a reversible thermosensor to regulate PP1 activity • Temperature shifts the PP1-RIOK2 balance to control CLK1 Ser341 phosphorylation
Keywords:
thermosensor
splicing regulation
nuclear stress body
protein kinase
protein phosphatase
protein localization
intrinsically disordered protein
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Journal

Molecular Cell cover
Molecular Cell
IF:
16.6
Papers:
1.0W
Citations:
8.5W

Organization

N
national cancer center research institute
Scholars:
217
Papers: 76
Citations: 0
U
University of Osaka
Scholars:
4.1K
Papers: 1.3K
Citations: 1
H
hokkaido university
Scholars:
4.0K
Papers: 1.5K
Citations: 0
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