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Thiol-functionalized polylysine as macro antibacterial thiol-norbornene crosslinker for constructing 3D-bioprinted wound healing scaffolds
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DOI：10.1016/j.polymertesting.2026.109244.png)
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Abstract
En 中文
• A new strategy to synthesize norbornene-modified gelatin (GelNB) was introduced by utilizing norbornene-2-carboxylic anhydride. The synthesized GelNB showed great compatibility with positively charged thiolate ε- Polylysine (PLSH). • Compared with the GelMA or GelNB/DTT, the developed GelNB/PLSH exhibited superior photo-crosslinking reactivity, bioactivity, and printability. • Both GelNB/PLSH solution and hydrogel exhibited broad-spectrum antibacterial ability without the addition of any antibacterial additives. • The rat adipose-derived stem cells (ADSCs)-laden GelNB/PLSH scaffolds enhanced the wound healing outcomes of full-thickness skin defects.
Keywords:
3D bioprinting
Thiolate polylysine
Thiol-ene
rADSCs
Antibacterial
Wound healing
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