Thymoquinone enhances kidney function in obesity-induced renal impairment by targeting redox balance, inflammation, autophagy, and apoptosis

Mostafa D. Mostafa

doi:10.1016/j.tice.2026.103568

Thymoquinone enhances kidney function in obesity-induced renal impairment by targeting redox balance, inflammation, autophagy, and apoptosis

2026-05-04

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AI

M

Mostafa D. Mostafa

M

Maggie E. Amer

M

Magda A. Elkomy

A

Azza I. Othman

M

Mohamed A. El‑Missiry *

DOI：10.1016/j.tice.2026.103568

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Abstract

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• Thymoquinone (TQ) reverses HFD-induced kidney dysfunction (creatinine, urea, uric acid) and tubular damage (KIM-1, NGAL). • TQ restores podocyte integrity, evidenced by increased podocin and nephrin levels. • TQ orchestrates a novel regulation of autophagy flux and mitigates DNA damage in renal tissue. • TQ inhibits mitochondrial apoptosis, providing a multi-pathway defense against obesity-related nephropathy.

Keywords:

Thymoquinone

kidney function

autophagy

apoptosis

inflammation

Thymoquinone enhances kidney function in obesity-induced renal impairment by targeting redox balance, inflammation, autophagy, and apoptosis

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