.png){kind=icon}
返回
Thyroid Function Test Abnormalities in Twin Pregnancies
.png){kind=icon}
PRE
AI
DOI：10.1089/thy.2020.0348.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Background:Compared with singletons, a twin pregnancy is associated with a larger thyroid hormone demand and an increased stimulation of gestational thyroid function due to higher concentrations of human chorionic gonadotropin. However, such effects have been sparsely quantified. The aim of this study was to evaluate thyroid function and thyroid function test abnormalities in twin pregnancies during early and late pregnancy compared with singletons. Methods:We included 1208 twin pregnancies and 46,834 singleton pregnancies with thyroid function tests available. Thyroid function test abnormalities were defined using population-based reference ranges. The analyses were adjusted for potential confounders including maternal age and body mass index. Results:Compared with singletons, a twin pregnancy was associated with a lower thyrotropin (TSH) (beta = -0.46 [95% confidence interval, CI -0.49 to -0.44],p < 0.001) and a higher free thyroxine (fT4) (beta = 0.91 [CI 0.69-1.16],p < 0.001) during early pregnancy. During late pregnancy, a twin pregnancy was associated with a higher TSH (beta = 0.35 [CI 0.29-0.42],p < 0.001) while fT4 did not differ (beta = -0.11 [CI -0.22 to 0.01],p = 0.065). During early pregnancy, a twin pregnancy was associated with a higher risk of overt hyperthyroidism (odds ratio, OR = 7.49 [CI 6.02-9.33],p < 0.001), subclinical hyperthyroidism (OR = 5.26 [CI 4.17-6.64],p < 0.001), and isolated hypothyroxinemia (OR = 1.89 [CI 1.43-2.49],p < 0.001), but with a lower risk of subclinical hypothyroidism (OR = 0.27 [CI 0.13-0.54],p < 0.001). In late pregnancy, a twin pregnancy was associated with a higher risk of subclinical hypothyroidism (OR = 4.05 [CI 3.21-5.11],p < 0.001), isolated hypothyroxinemia (OR = 1.48 [CI 1.04-2.10],p = 0.028), and subclinical hyperthyroidism (OR = 1.76 [CI 1.27-2.43],p < 0.001). Conclusions:During early pregnancy, a twin pregnancy was associated with a higher thyroid function and a higher risk of (subclinical) hyperthyroidism, as well as a higher risk of isolated hypothyroxinemia. During late pregnancy, a twin pregnancy was associated with a higher TSH concentration and a higher risk of subclinical hypothyroidism, as well as a persistently higher risk of isolated hypothyroxinemia and subclinical hyperthyroidism. The study was approved by Chinese Clinical Trial Registry (registration no. ChiCTR1800014394).
Keyword:
thyroid
dysfunction
TSH
fT4
twin pregnancy
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
6.7
论文数:
5.9K
被引数:
1.6W
机构
引用论文
分享收藏分享收藏2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum.png)
THYROID
OAAI
THYROIDIF6.7
OAAI分享收藏
查看更多内容