Tight Junction Structure and Function Revisited

doi:10.1016/j.tcb.2020.08.004

2020-10-01

397

PRE

Tetsuhisa Otani *

Mikio Furuse

DOI：10.1016/j.tcb.2020.08.004

原文链接

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摘要

En 中文

Tight junctions (TJs) are intercellular junctions critical for building the epithelial barrier and maintaining epithelial polarity. The claudin family of membrane proteins play central roles in TJ structure and function. However, recent findings have uncovered claudin-independent aspects of TJ structure and function, and additional players including junctional adhesion molecules (JAMs), membrane lipids, phase separation of the zonula occludens (ZO) family of scaffolding proteins, and mechanical force have been shown to play important roles in TJ structure and function. In this review, we discuss how these new findings have the potential to transform our understanding of TJ structure and function, and how the intricate network of TJ proteins and membrane lipids dynamically interact to drive TJ assembly.

Keyword:

PROTEIN-KINASE-C

ADHESION MOLECULE

OCCLUDIN PHOSPHORYLATION

JAM-A

POSSIBLE INVOLVEMENT

PHASE-SEPARATION

CLAUDIN STRANDS

ZONULA ADHERENS

DIRECT BINDING

ZO-1

AI总结

对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。

期刊

Trends in Cell Biology

IF:

18.1

论文数:

3.1K

被引数:

2.0W

机构

national institutes of natural sciences (nins) - japan

学者数:

8.6K

论文数: 9.1K

被引数: 3

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