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TIGRa: An ultra-compact programmable activator enabling multiplexed and efficient gene regulation
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DOI：10.1016/j.stem.2026.07.008.png)
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Abstract
En 中文
• TIGRa enables potent gene activation with an ultra-miniature design • Native TIGR arrays support simultaneous activation of up to 12 genes • Single-AAV TIGRa protects retinal ganglion cells and preserves vision
Keywords:
TIGRa
CRISPR activation
transcriptional activator
TIGR-TasR
TIGR array
multiplexed activation
RGC protection
glaucoma
AAV delivery
gene therapy
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