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Time-dependent analysis of bronchus-associated lymphoid tissue formation and pulmonary inflammation induced by various particulate matter in asthmatic mice model
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DOI：10.1016/j.jhazmat.2026.143239.png)
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Abstract
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• Repeated particulate exposure induces time-dependent BALT formation. • Early IL-1α elevation contributes to BALT development under OVA conditions. • CXCL1 and neutrophil infiltration are associated with BALT formation without OVA. • 3D reconstruction revealed BALT extension toward the distal airways. • TiO₂ was confirmed in alveoli, macrophages, and lymphoid tissues.
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11.3
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