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Timing Rules for Synaptic Plasticity Matched to Behavioral Function
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DOI：10.1016/j.neuron.2016.10.022.png)
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摘要
En 中文
It is widely assumed that the complexity of neural circuits enables them to implement diverse learning tasks using just a few generic forms of synaptic plasticity. In contrast, we report that synaptic plasticity can itself be precisely tuned to the requirements of a learning task. We found that the rules for induction of long-term and single-trial plasticity at parallel fiber-to-Purkinje cell synapses vary across cerebellar regions. In the flocculus, associative plasticity in vitro and in vivo is narrowly tuned for an interval of similar to 120 ms, which compensates for the specific processing delay for error signals to reach the flocculus during oculomotor learning. In the vermis, which supports a range of behavioral functions, plasticity is induced by a range of intervals, with individual cells tuned for different intervals. Thus, plasticity at a single, anatomically defined type of synapse can have properties that vary in a way that is precisely matched to function.
Keyword:
LONG-TERM DEPRESSION
CEREBELLAR PURKINJE-CELLS
PURSUIT EYE-MOVEMENTS
VESTIBULOOCULAR REFLEX
MOTOR
DEPENDENCE
MEMORY
OSCILLATIONS
COINCIDENCE
EXPRESSION
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期刊
IF:
15
论文数:
1.4W
被引数:
9.9W
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