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TNF and MAP kinase signalling pathways
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DOI：10.1016/j.smim.2014.02.009.png)
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The binding of tumour necrosis factor alpha (TNF alpha) to cell surface receptors engages multiple signal transduction pathways, including three groups of mitogen-activated protein (MAP) kinases: extracellular-signal-regulated kinases (ERKs); the cJun NH2-terminal kinases (JNKs); and the p38 MAP kinases. These MAP kinase signalling pathways induce a secondary response by increasing the expression of several inflammatory cytokines (including TNF alpha) that contribute to the biological activity of TNF alpha. MAP kinases therefore function both upstream and down-stream of signalling by TNFa receptors. Here we review mechanisms that mediate these actions of MAP kinases during the response to TNF alpha. (C) 2014 Elsevier Ltd. All rights reserved.
Keyword:
TNF
MAP kinase
ERK
JNK
p38 MAP kinase
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TAK1 Negatively Regulates NF-κB and p38 MAP Kinase Activation in Gr-1+CD11b+ Neutrophils.png)
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