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TNF-α-mediated down-regulation of mitochondrial transcription factors: Rescue by Angiotensin-(1–7) peptide
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DOI：10.1016/j.mito.2026.102130.png)
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Abstract
En 中文
• The study investigated regulation of mitochondrial transcription factors (mtTFs) • mtTFs are repressed in the left ventricle of genetically-hypertensive rats. • TNF-α diminished the expression of mtTFs in cardiomyocytes. • Ang-(1–7), an anti-inflammatory and anti-hypertensive peptide, reversed the effects of TNF-ɑ. • PGC-1ɑ-YY1 transcriptional complex acts as a key modulator of the mtTFs.
Keywords:
mitochondrial transcription factors
TNF-α
Angiotensin-(1–7)
PGC-1ɑ-YY1 complex
cardiomyocytes
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