Tolerance-Is It Worth It?

Erik B. Finger

doi:10.1101/cshperspect.a015594

Tolerance-Is It Worth It?

2013-12-26

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DOI：10.1101/cshperspect.a015594

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We are entering an exciting time in the study of immunologic tolerance. Several cellular and molecular strategies have been developed that show promise in nonhuman transplant models and these approaches are just now appearing in clinical trials. Tolerance strategies that prevent immune rejection and obviate the need for immunosuppressive medications (with inherent risk of cancer, infection, and organ toxicity) would improve both graft and patient survival. Each tolerance protocol brings its ownset of associated risks. As the results of these trials become available, we must continue to evaluate their successes and failures. The balance of these outcomes will help us answer the question: Tolerance-Is it worth it?

Keyword:

BONE-MARROW-TRANSPLANTATION

PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY

CLINICAL OPERATIONAL TOLERANCE

REGULATORY T-CELLS

LONG-TERM SURVIVAL

RENAL-TRANSPLANTATION

KIDNEY-TRANSPLANTATION

MONOCLONAL-ANTIBODY

ALLOGRAFT SURVIVAL

PHASE-III

Tolerance-Is It Worth It?

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