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Topic: Continuous Enzymatic Peracids Synthesis in Pickering Emulsions: Influence of Nanoparticles Modification, Aqueous Phase Composition and Operational Parameters
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DOI：10.1002/elsc.70077.png)
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Abstract
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The lipase-catalyzed oxidative functionalization of alkenes in Pickering emulsions (PE) offers a green and efficient alternative to conventional processes involving hazardous oxidants. Other investigated reaction media used for this alternative green pathway still suffer from enzyme deactivation and /or low specific reaction rate which limits their industrial adaptability. This study investigates the enzymatic synthesis of peroxyacetic acid, the first step in lipase-catalyzed oxidative functionalization, in a continuous membrane reactor. The effects of aqueous phase composition, modified silica nanoparticles, and operational parameters on reaction performance were systematically studied. Optimal conditions were obtained at pH 7, 100 mM buffer, and 5 g Ldp−1 enzyme concentration. Surface-modified silica nanoparticles improved PE stability and interfacial catalytic efficiency, while maintaining comparable catalytic productivity. Hydrogen peroxide outperformed urea hydrogen peroxide, yielding a maximum product yield of 83% at a concentration of 45 mM in the influent solution and a space-time yield of 44.9 gPAL−1d−1 at 386 mM. At 386 mM, the specific reaction rate (17.5 mmol g−1 h−1) was over twice that of reported single organic-phase systems. Despite the high peroxide concentrations, the enzyme displayed remarkable stability in PE due to the protective role of nanoparticles. This work provides critical insights into optimizing enzymatic oxidative functionalization in PE and their potential for sustainable industrial applications.
Keywords:
Candida antarctica Lipase B
enzyme deactivation
membrane reactor
peroxyacetic acids
Pickering emulsions
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