Topographic Mapping-The Olfactory System

Takeshi Imai

doi:10.1101/cshperspect.a001776

Topographic Mapping-The Olfactory System

2010-06-16

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DOI：10.1101/cshperspect.a001776

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Sensory systems must map accurate representations of the external world in the brain. Although the physical senses of touch and vision build topographic representations of the spatial coordinates of the body and the field of view, the chemical sense of olfaction maps discontinuous features of chemical space, comprising an extremely large number of possible odor stimuli. In both mammals and insects, olfactory circuits are wired according to the convergence of axons from sensory neurons expressing the same odorant receptor. Synapses are organized into distinctive spherical neuropils-the olfactory glomeruli-that connect sensory input with output neurons and local modulatory interneurons. Although there is a strong conservation of form in the olfactory maps of mammals and insects, they arise using divergent mechanisms. Olfactory glomeruli provide a unique solution to the problem of mapping discontinuous chemical space onto the brain.

Keyword:

DROSOPHILA ANTENNAL LOBE

ODORANT RECEPTOR GENES

SENSORY NEURONS

PROJECTION NEURONS

AXON GUIDANCE

WIRING SPECIFICITY

ZONAL TOPOGRAPHY

MOLECULAR-BASIS

MICE DEFICIENT

N-CADHERIN

Topographic Mapping-The Olfactory System

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