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Topological data analysis communities reveal gene-environment-brain subtypes of major depression in UK Biobank and multi-site cohorts.
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DOI:10.1016/j.biopsych.2026.06.030.png)
Abstract
En 中文
Major depressive disorder (MDD) exhibits substantial clinical heterogeneity complicating prognosis and treatment. Characterizing MDD subtypes could enhance personalized approaches. We developed a topological data analysis (TDA) framework with graph-based community detection to identify patient subgroups using multimodal data.
Keywords:
Major depressive disorder
Multimodality
Topological data analysis
Community detection
Journal
IF:
9
Papers:
1.5W
Citations:
4.0W
