Toxicity during induction of pulsed versus continuous prednisolone in children with acute lymphoblastic leukaemia: a multi-centre, open label, randomised, phase 3 trial from India (2016–2022)

2026-06-07

Parag Das

Nandana Das

Gaurav Narula

Amita Trehan

Sameer Bakhshi

Venkatraman Radhakrishnan

Rachna Seth

Prashant Tembhare

Man Updesh Singh Sachdeva

Anita Chopra

Shirley Sundersingh

Soumyadeep Das

Manash Pratim Gogoi

Mayur Parihar

Rahul Bhattacharya

Shripad Banavali

Vaskar Saha *

Krishnan, Shekhar FRCPath, PhD, †

DOI：10.1016/j.lansea.2026.100788

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Despite the use of similar treatment protocols, induction treatment-related mortality (TRM) in children with ALL in India is 5%, compared to <1% in high income countries. This study evaluated pulsed prednisolone during induction to reduce toxicity.

Keywords:

Acute lymphoblastic leukaemia

Child

Steroid

Randomised clinical trial

Toxicity during induction of pulsed versus continuous prednisolone in children with acute lymphoblastic leukaemia: a multi-centre, open label, randomised, phase 3 trial from India (2016–2022)

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