.png){kind=icon}
返回
Tract-specific statistics based on diffusion-weighted probabilistic tractography
.png){kind=icon}
OA
AI
DOI：10.1038/s42003-022-03073-w.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Diffusion-weighted neuroimaging approaches provide rich evidence for estimating the structural integrity of white matter in vivo, but typically do not assess white matter integrity for connections between two specific regions of the brain. Here, we present a method for deriving tract-specific diffusion statistics, based upon predefined regions of interest. Our approach derives a population distribution using probabilistic tractography, based on the Nathan Kline Institute (NKI) Enhanced Rockland sample. We determine the most likely geometry of a path between two regions and express this as a spatial distribution. We then estimate the average orientation of streamlines traversing this path, at discrete distances along its trajectory, and the fraction of diffusion directed along this orientation for each participant. The resulting participant-wise metrics (tract-specific anisotropy; TSA) can then be used for statistical analysis on any comparable population. Based on this method, we report both negative and positive associations between age and TSA for two networks derived from published meta-analytic studies (the default mode and what-where networks), along with more moderate sex differences and age-by-sex interactions. The proposed method can be applied to any arbitrary set of brain regions, to estimate both the spatial trajectory and DWI-based anisotropy specific to those regions. Andrew Reid et al. use publicly available data to present a method for deriving tract-specific statistics based on diffusion-weighted MRI, based upon arbitrarily-defined regions of interest. Their approach enables them to report both negative and positive associations between age and tract-specific anisotropy along with more moderate sex differences and age-by-sex interactions.
Keyword:
WHITE-MATTER INTEGRITY
MILD COGNITIVE IMPAIRMENT
AGE-RELATED DIFFERENCES
DEFAULT MODE NETWORK
HUMAN BRAIN
FRACTIONAL ANISOTROPY
SPATIAL STATISTICS
CORTICAL THICKNESS
VOXELWISE ANALYSIS
CORPUS-CALLOSUM
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
5.1
论文数:
1.0W
被引数:
3.2W
机构
引用论文
Alcoholysis of tri-tert-butylgallium: synthesis and structural characterization of [(But)2Ga(μ-OR)]2.png)
Polyhedron
PolyhedronIF0
PREAI
分享收藏
分享收藏
查看更多内容