Transaminase biocatalysis: optimization and application

Fei Guo

doi:10.1039/c6gc02328b

2017-01-01

354

Fei Guo

Per Berglund *

DOI：10.1039/c6gc02328b

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摘要

En 中文

Transaminases (TAs) are one of the most promising biocatalysts in organic synthesis for the preparation of chiral amino compounds. The concise reaction, excellent enantioselectivity, environmental friendliness and compatibility with other enzymatic or chemical systems have brought TAs to the attention of scientists working in the area of biocatalysis. However, to utilize TAs in a more efficient and economical way, attempts have to be made to optimize their performance. The demand for various substrate specificities, stability under non-physiological conditions and higher conversions in reversible reactions have been targeted and investigated thoroughly. A number of both protein- and process-based strategies have been developed to improve TAs and systems involving TAs. Moreover, by combination with other enzymes in cascade reactions or even in more complex systems, so called synthetic biology and systems biocatalysis, TAs can be biocatalysts with immense potential in the industrial production of high-value chemical products. This review will highlight strategies for optimization of TAs and will discuss a number of elegant systems for improving their performance. Transaminase biocatalysis has been, and will continue to be, one of the most interesting topics in green organic synthesis.

Keyword:

BETA-AMINO ACIDS

CATALYZED ASYMMETRIC-SYNTHESIS

EMPLOYING OMEGA-TRANSAMINASES

ENGINEERED ESCHERICHIA-COLI

VIBRIO-FLUVIALIS JS17

CHIRAL AMINES

ONE-POT

SUBSTRATE-SPECIFICITY

KINETIC RESOLUTION

PYRUVATE TRANSAMINASE

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期刊

Green Chemistry

IF:

9.2

论文数:

1.3W

被引数:

7.6W

机构

Royal Institute of Technology

学者数:

1.8W

论文数: 1.8W

被引数: 25

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