.png){kind=icon}
返回
Transcriptomics: a Solution for Renal Osteodystrophy?
.png){kind=icon}
OA
AI
DOI：10.1007/s11914-020-00583-6.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Purpose of Review The molecular mechanisms of the bone disease associated with chronic kidney disease (CKD), called renal osteodystrophy (ROD), are poorly understood. New transcriptomics technologies may provide clinically relevant insights into the pathogenesis of ROD. This review summarizes current progress and limitations in the study and treatment of ROD, and in transcriptomics analyses of skeletal tissues. Recent Findings ROD is characterized by poor bone quality and strength leading to increased risk of fracture. Recent studies indicate permanent alterations in bone cell populations during ROD. Single-cell transcriptomics analyses, successful at identifying specialized cell subpopulations in bone, have not yet been performed in ROD. ROD is a widespread poorly understood bone disease with limited treatment options. Transcriptomics analyses of bone are needed to identify the bone cell subtypes and their role in the pathogenesis of ROD, and to develop adequate diagnosis and treatment strategies.
Keyword:
Renal osteodystrophy
Bone and mineral metabolism
Chronic kidney disease
Transcriptomics
Bulk RNA sequencing
Single-cell RNA sequencing
期刊
C
IF:
8.1
论文数:
1.7K
被引数:
4.6K
机构
引用论文
Inducible podocyte-specific deletion of CTCF drives progressive kidney disease and bone abnormalities.png)
JCI INSIGHTOAAI
JCI INSIGHTIF6.1
OAAI分享收藏分享收藏DMP1 prevents osteocyte alterations, FGF23 elevation and left ventricular hypertrophy in mice with chronic kidney diseaseBONE RESEARCH
OAAI
BONE RESEARCHIF15
OAAI分享收藏
查看更多内容