Translocation at work

doi:10.1038/nsmb.2661

2013-09-05

PRE

John Achenbach *

Knud H. Nierhaus

DOI：10.1038/nsmb.2661

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摘要

En 中文

Translocation is an essential step of protein synthesis in which the large tRNA(2)-mRNA complex inside the ribosome moves from the A and P sites to the P and E sites, respectively, bringing a new mRNA codon into the decoding center. This process is catalyzed by the elongation factor EF-G-GTP (eEF2 in eukaryotes) and is the least understood stage of peptide elongation. Four new reports describe the crystal structures of translocation intermediates, illustrating important details of the translocation reaction.

Keyword:

CRYSTAL-STRUCTURE

MESSENGER-RNA

RIBOSOMAL TRANSLOCATION

GTP HYDROLYSIS

ACTIVATION

STATE

MECHANISM

BINDING

SITE

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期刊

Nature Structural and Molecular Biology

IF:

10.1

论文数:

4.8K

被引数:

2.8W

机构

Berlin Institute of Health

学者数:

3.9W

论文数: 3.0W

被引数: 6.6K

noxxon pharma

学者数:

论文数: 32

被引数: 0

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