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Troxerutin Attenuates Paclitaxel-induced Cardiotoxicity Through Modulation of Ferroptosis and GRP78/ATF6/CHOP Signaling in Rats

delete2026-05-06
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PRE
AI
Y
Yasmine M. El-Naggar
S
Sara El Wakeel
M
Mina Y. George *
D
Doaa A. Elsherbiny
DOI：10.1016/j.ejphar.2026.178944delete
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Abstract

Abstract

En 中文
• Troxerutin corrected histological alterations induced by Paclitaxel in rats. • Troxerutin restored normal oxidative balance following chemotherapy treatment. • Via regulation of ferroptosis, Troxerutin counteracted cardiac injury in rats. • Modulation of endoplasmic reticulum stress may provide evidence behind Troxerutin cardioprotective actions. • Troxerutin did not abrogate the anti-cancer activity of Paclitaxel on human MDA-MB cells.
Keywords:
Troxerutin
Paclitaxel-induced cardiotoxicity
Ferroptosis
GRP78/ATF6/CHOP signaling
Cardioprotection

Journal

European Journal of Pharmacology cover
European Journal of Pharmacology
IF:
4.7
Papers:
2.3W
Citations:
4.0W

Organization

M
misr international university
Scholars:
258
Papers: 209
Citations: 8
A
ain shams university
Scholars:
2.1K
Papers: 993
Citations: 0
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