.png){kind=icon}
返回
TRP channels
.png){kind=icon}
PRE
AI
DOI：10.1016/j.coph.2015.02.006.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Evidence is accumulating on the role of transient receptor potential (TRP) channels, namely TRPV1, TRPA1, TRPV4 and TRPM8, expressed by C- and A delta-fibres primary sensory neurons, in cough mechanism. Selective stimuli for these channels have been proven to provoke and, more rarely, to inhibit cough. More importantly, cough threshold to TRP agonists is increased by proinflammatory conditions, known to favour cough. Off-target effects of various drugs, such as tiotropium or desflurane, seem to produce their protective or detrimental actions on airway irritation and cough via TRPV1 and TRPA1, respectively. Thus, TRPs appear to encode the process that initiates or potentiates cough, activated by exogenous irritants and endogenous proinflammatory mediators. More research on TRP channels may result in innovative cough medicines.
Keyword:
RECEPTOR POTENTIAL CHANNELS
PARTICULATE MATERIAL
REFLEX SENSITIVITY
ANKYRIN-1 TRPA1
TRANSIENT
COUGH
NEURONS
DISEASE
TIOTROPIUM
MECHANISM
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
4.2
论文数:
2.5K
被引数:
6.7K
机构
引用论文
.png){kind=icon}
查看更多内容