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Tumoral AMER1 driven dopamine synthesis triggers cancer cell pyroptosis and licenses CD8+ T cell immunity in colorectal cancer
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DOI：10.1016/j.canlet.2026.218772.png)
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Abstract
En 中文
• AMER1 loss in CRC correlates with advanced staging and CD8+ T cell exclusion. • AMER1 physically binds and shields DDC from degradation to drive dopamine synthesis. • Tumoral dopamine accumulation triggers GSDMD-dependent cancer cell pyroptosis. • Dopamine therapy reverses CD8+ T cell terminal exhaustion to halt CRC progression.
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