Tumour progression shows decrease in PD-L1 expression in matched metastases/primary uveal melanomas

Maria Chiara Gelmi

doi:10.1111/aos.17559

2025-07-24

DOI：10.1111/aos.17559

原文链接

原文求助

摘要

En 中文

免疫检查点抑制剂（ICI）已彻底改变了多种恶性肿瘤的治疗方法。然而，ICI疗法在转移性眼葡萄膜黑色素瘤（UM）中的效果仍然不理想。我们分析了PD1、PD-L1、T细胞和巨噬细胞标志物在匹配的原发性和转移性UM样本中的表达，试图更深入地理解ICI在转移性UM中效果不佳的原因。

Keyword:

immune checkpoint

metastases

microenvironment

uveal melanoma

期刊

Acta Ophthalmologica

IF:

2.8

论文数:

1.1W

被引数:

1.1W

机构

Leiden University Medical Center

学者数:

1.8K

论文数: 633

被引数: 3.0W

引用论文

Current state of immune checkpoints therapy for glioblastoma 胶质母细胞瘤免疫检查点治疗的现状

HELIYON

IF3.6

2024-01-01

OAAI

Wang, He; Yang, Jing; Li, Xiangjun; Zhao, Hai

Pembrolizumab for the Treatment of Non-Small-Cell Lung Cancer Pembrolizumab治疗非小细胞肺癌

NEW ENGLAND JOURNAL OF MEDICINE

IF78.5

2015-05-21

5.2K

OAAI

Garon, Edward B.; Rizvi, Naiyer A.; Hui, Rina; Leighl, Natasha; Balmanoukian, Ani S.; Eder, Joseph Paul; Patnaik, Amita; Aggarwal, Charu; Gubens, Matthew; Horn, Leora; Carcereny, Enric; Ahn, Myung-Ju; Felip, Enriqueta; Lee, Jong-Seok; Hellmann, Matthew D.; Hamid, Omid; Goldman, Jonathan W.; Soria, Jean-Charles; Dolled-Filhart, Marisa; Rutledge, Ruth Z.; Zhang, Jin; Lunceford, Jared K.; Rangwala, Reshma; Lubiniecki, Gregory M.; Roach, Charlotte; Emancipator, Kenneth; Gandhi, Leena

The Role of Immune Checkpoint Blockade in Uveal Melanoma

International Journal of Molecular Sciences

IF0

2020-01-29

OAAI

Anja Wessely; Theresa Steeb; Michael Erdmann; Lucie Heinzerling; Julio Vera; Max Schlaak; Carola Berking; Markus Vincent Heppt

Anti-PD1 treatment in metastatic uveal melanoma in the Netherlands

Acta Oncologica

IF0

2016-12-02

OAAI

M. K. van der Kooij; A. Joosse; F. M. Speetjens; G. A. P. Hospers; C. Bisschop; J. W. B. de Groot; R. Koornstra; C. U. Blank; E. Kapiteijn

PD-L1 Expression in Tumor Metastasis is Different Between Uveal Melanoma and Cutaneous Melanoma

Immunotherapy

IF0

2017-11-29

OAAI

Asad Javed; David Arguello; Curtis Johnston; Zoran Gatalica; Mizue Terai; Ryan M Weight; Marlana Orloff; Michael J Mastrangelo; Takami Sato

Outlier response to anti-PD1 in uveal melanoma reveals germline MBD4 mutations in hypermutated tumors

NATURE COMMUNICATIONS

IF15.7

2018-05-14

102

OAAI

Rodrigues, Manuel; Mobuchon, Lenha; Houy, Alexandre; Fievet, Alice; Gardrat, Sophie; Barnhill, Raymond L.; Popova, Tatiana; Servois, Vincent; Rampanou, Aurore; Mouton, Aurore; Dayot, Stephane; Raynal, Virginie; Galut, Michele; Putterman, Marc; Tick, Sarah; Cassoux, Nathalie; Roman-Roman, Sergio; Bidard, Francois-Clement; Lantz, Olivier; Mariani, Pascale; Piperno-Neumann, Sophie; Stern, Marc-Henri

Detection of M2-Macrophages in Uveal Melanoma and Relation with Survival

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

IF4.7

2011-02-02

182

PREAI

Bronkhorst, Inge H. G.; Ly, Long V.; Jordanova, Ekaterina S.; Vrolijk, Johannes; Versluis, Mieke; Luyten, Gregorius P. M.; Jager, Martine J.

Expression of immune checkpoint receptors Indoleamine 2,3‐dioxygenase and T cell Ig and ITIM domain in metastatic versus nonmetastatic choroidal melanoma

Cancer Medicine

IF0

2019-04-16

OAAI

Gustav Stålhammar; Stefan Seregard; Hans E. Grossniklaus

Inflammatory cell infiltrates in advanced metastatic uveal melanoma

Human Pathology

IF0

2017-08-01

PREAI

Yamini Krishna; Conni McCarthy; Helen Kalirai; Sarah E. Coupland

MBD4 deficiency is predictive of response to immune checkpoint inhibitors in metastatic uveal melanoma patients

EUROPEAN JOURNAL OF CANCER

IF7.1

2022-09-01

PREAI

Saint-Ghislain, Mathilde; Derrien, Anne-Celine; Geoffrois, Lionnel; Gastaud, Lauris; Lesimple, Thierry; Negrier, Sylvie; Penel, Nicolas; Kurtz, Jean-Emmanuel; Le Corre, Yannick; Dutriaux, Caroline; Gardrat, Sophie; Barnhill, Raymond; Matet, Alexandre; Cassoux, Nathalie; Houy, Alexandre; Ramtohul, Toulsie; Servois, Vincent; Mariani, Pascale; Piperno-Neumann, Sophie; Stern, Marc-Henri; Rodrigues, Manuel

查看更多内容