Turning garbage into gold: Autophagy in synaptic function

Erin Smith

doi:10.1016/j.conb.2024.102937

2025-02-01

PRE

Erin Smith

Maeve Coughlan

Sandra Maday

DOI：10.1016/j.conb.2024.102937

原文链接

原文求助

摘要

En 中文

人类大脑中的数万亿个突触实现了思维和行为。突触连接必须建立并维持，同时保留动态灵活性以应对经验。这些过程需要突触的主动重塑来调控蛋白质和细胞器的组成与完整性。巨自噬（以下简称自噬）提供了一种编辑和修剪突触蛋白质组（synaptic proteome）的机制。经典上，自噬被视为一种稳态过程，用于清除衰老和损伤的蛋白质以维持神经元存活。然而，越来越多的证据表明，自噬还会在响应神经元活动时降解特定货物（cargoes），从而影响神经元传递、兴奋性和突触可塑性。在此，我们将讨论神经元自噬在突触功能中的多样化作用、调控及机制，以及胶质细胞自噬在这些过程中的贡献。

Keyword:

NEURONS

BASSOON

MACROAUTOPHAGY

PLASTICITY

期刊

Current Opinion in Psychiatry

IF:

4.9

论文数:

2.9K

被引数:

6.2K

机构

Univ Penn

学者数:

4.0K

论文数: 2.6K

被引数: 726

引用论文

Autophagosome maturation: An epic journey from the ER to lysosomes

JOURNAL OF CELL BIOLOGY

IF6.4

2018-12-21

242

OAAI

Zhao, Yan G.; Zhang, Hong

Oligodendroglia are emerging players in several forms of learning and memory

COMMUNICATIONS BIOLOGY

IF5.1

2022-10-29

OAAI

Munyeshyaka, Maxime; Fields, R. Douglas

Profiling of purified autophagic vesicle degradome in the maturing and aging brain

NEURON

IF15

2023-08-01

OAAI

Kallergi, Emmanouela; Sankar, Devanarayanan Siva; Matera, Alessandro; Kolaxi, Angeliki; Paolicelli, Rosa Chiara; Dengjel, Joern; Nikoletopoulou, Vassiliki

Regulation of Presynaptic Neurotransmission by Macroautophagy

NEURON

IF15

2012-04-01

292

OAAI

Hernandez, Daniela; Torres, Clara A.; Setlik, Wanda; Cebrian, Carolina; Mosharov, Eugene V.; Tang, Guomei; Cheng, Hsiao-Chun; Kholodilov, Nikolai; Yarygina, Olga; Burke, Robert E.; Gershon, Michael; Sulzer, David

Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease

NATURE COMMUNICATIONS

IF15.7

2017-10-30

OAAI

Lueningschroer, Patrick; Binotti, Beyenech; Dombert, Benjamin; Heimann, Peter; Perez-Lara, Angel; Slotta, Carsten; Thau-Habermann, Nadine; von Collenberg, Cora R.; Karl, Franziska; Damme, Markus; Horowitz, Arie; Maystadt, Isabelle; Fuechtbauer, Annette; Fuechtbauer, Ernst-Martin; Jablonka, Sibylle; Blum, Robert; Ueceyler, Nurcan; Petri, Susanne; Kaltschmidt, Barbara; Jahn, Reinhard; Kaltschmidt, Christian; Sendtner, Michael

Cell-type-specific regulation of neuronal intrinsic excitability by macroautophagy

ELIFE

IF0

2020-01-08

OAAI

Lieberman, Ori J.; Frier, Micah D.; McGuirt, Avery F.; Griffey, Christopher J.; Rafikian, Elizabeth; Yang, Mu; Yamamoto, Ai; Borgkvist, Anders; Santini, Emanuela; Sulzer, David

Autophagy Is Required for Memory Formation and Reverses Age-Related Memory Decline

CURRENT BIOLOGY

IF7.5

2019-02-01

193

OAAI

Glatigny, Melissa; Moriceau, Stephanie; Rivagorda, Manon; Ramos-Brossier, Mariana; Nascimbeni, Anna C.; Lante, Fabien; Shanley, Mary R.; Boudarene, Nadir; Rousseaud, Audrey; Friedman, Allyson K.; Settembre, Carmine; Kuperwasser, Nicolas; Friedlander, Gerard; Buisson, Alain; Morel, Etienne; Codogno, Patrice; Oury, Franck

The role of mitophagy in the regulation of mitochondrial energetic status in neurons 线粒体吞噬在神经元线粒体能量状态调节中的作用

AUTOPHAGY

IF14.3

2021-04-05

OAAI

Han, Sinsuk; Zhang, Mingyang; Jeong, Yu Young; Margolis, David J.; Cai, Qian

ATG9 vesicles comprise the seed membrane of mammalian autophagosomes

JOURNAL OF CELL BIOLOGY

IF6.4

2023-04-28

OAAI

Olivas, Taryn J. J.; Wu, Yumei; Yu, Shenliang; Luan, Lin; Choi, Peter; Guinn, Emily D. D.; Nag, Shanta; De Camilli, Pietro V. V.; Gupta, Kallol; Melia, Thomas J. J.

Autophagy in axonal and presynaptic development

Current Opinion in Neurobiology

IF0

2021-08-01

OAAI

Oliver Crawley; Brock Grill

查看更多内容