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Ultrasound-assisted deep eutectic solvent extraction of green, high-efficient, and high-bioactive polysaccharides from Glycyrrhiza uralensis
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DOI：10.1016/j.ultsonch.2026.108001.png)
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Abstract
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• Ultrasound-assisted deep eutectic solvent extraction (UDE) achieved a maximum polysaccharide yield of 18.56% with a 1.71-fold increase over hot water extraction. • UDE-extracted G. uralensis polysaccharides exhibited superior physicochemical properties of lower molecular weight, enhanced thermal stability, reduced particle size, and increased galacturonic acid content. • The DES system maintained high extraction efficiency over three consecutive recycling cycles, indicating good operational robustness and environmental sustainability. • The UDE-extracted polysaccharides showed potent antioxidant activity and suppressed IL-13-induced inflammation through the STAT6/MYD88 axis.
Keywords:
Glycyrrhiza uralensis polysaccharides
Ultrasound-assisted extraction
Deep eutectic solvents
Structural characterization
Antioxidant activity
Anti-inflammatory activity
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