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Ultrasound-Targeted Nanodroplets Destruction Activates CAF_Pi16-CCL7 Signaling to Enhance NKG2D Expression and Overcome ICB Resistance in MSS CRC

delete2026-07-29
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PRE
AI
B
Baojing Tuo
N
Na Li
S
Senbo Liu
S
Shuochen Gao
H
Hang Liu
L
Liping Pei
X
Xueyan Gao
K
Kaibo Li
Y
Yanxin Xu
Z
Zhenqiang Sun *
Y
Yan Zhang *
L
Lin Liu *
C
Chengzeng Wang *
DOI：10.1016/j.canlet.2026.218760delete
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Abstract

Abstract

En 中文
• Ultrasound-targeted nanodroplet destruction (UTND) overcomes ICB resistance in MSS colorectal cancer. • UTND induces oxidative stress in tumor cells, activating the AGE-RAGE pathway in CAF_Pi16. • CAF_Pi16 secretes CCL7, which upregulates NKG2D on CD8+ T cells to enhance tumor killing. • This study reveals a novel UTND-triggered CAF-Pi16-CCL7-NKG2D axis with high translational potential.

Journal

Cancer Letters cover
Cancer Letters
IF:
10.1
Papers:
1.7W
Citations:
4.3W

Organization

Z
zhengzhou university
Scholars:
9.4K
Papers: 2.7K
Citations: 2
T
the first affiliated hospital of zhengzhou university
Scholars:
2.2K
Papers: 665
Citations: 2
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