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Uncovering the neuroprotective mechanisms of the food–medicine homologous Zhengchan Formula in APP/PS1 mice: Mitophagy–mediated inhibition of NLRP3 inflammasome activation
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DOI：10.1016/j.jff.2026.107401.png)
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Abstract
En 中文
• ZCF effectively improved cognitive function and alleviated neuronal damage. • ZCF is a promising food–medicine homologous formula for the treatment of AD. • Mitophagy links neuroinflammation and gut-brain axis homeostasis.
Keywords:
Food–medicine homologous formula
Zhengchan formula
Alzheimer's disease
Cognitive function
NLRP3
Mitophagy
AD
Alzheimer's disease
ZCF
Zhengchan formula
NLRP3
NOD-, LRR- and pyrin domain-containing protein 3
ASC
apoptosis-associated speck-like protein containing a CARD
TCM
traditional Chinese medicine
UPLC-QTOF-HRMS/MS
ultra-performance liquid chromatography quadrupole time-of-flight high-resolution tandem mass spectrometry
Aβ42
amyloid β-Protein
TNF-α
tumor necrosis factor α
AST
aspartate aminotransferase
ALT
alanine aminotransferase
Cr
creatinine
BUN
blood urea nitrogen
TP
total protein
ALB
albumin
CHO
cholesterol
TG
triglycerides
CPK
creatine phosphokinase
HPLC
high-performance liquid chromatography
CK
vehicle-treated WT mice
MG
vehicle-treated APP/PS1 mice
ZCL
250 mg/kg ZCF-treated APP/PS1 mice
ZCM
500 mg/kg ZCF-treated APP/PS1 mice
ZCH
1000 mg/kg ZCF-treated APP/PS1 mice
DPZ
5 mg/kg donepezil-treated APP/PS1 mice
ZCH + Baf A1
1000 mg/kg ZCF + 1 mg/kg bafilomycin A1-treated APP/PS1 mice
OFT
open field test
YMT
Y-Maze Test
NOR
novel object recognition test
MWM
Morris water maze test.
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