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Undescribed and nephroprotective diterpenoids from Daphne genkwa
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DOI：10.1016/j.phytochem.2026.114830.png)
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Abstract
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Two previously undescribed lathyrane-type diterpenoids, daphngenoids A-B (1-2), and one new daphnane-type diterpenoid, daphngenoid C (3), along with eight known compounds (4-11), were isolated from the buds of Daphne genkwa. Notably, daphngenoids A-B (1-2) significantly inhibited doxorubicin-induced inflammation and oxidative stress in the human kidney proximal tubular epithelial cell line (HK-2).
Keywords:
Daphne genkwa
Thymelaeaceae
Diterpenoid
Daphngenoids A -C
Nephroprotective effect
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