Versatile Microfluidic Droplets Array for Bioanalysis

doi:10.1021/am5075216

2015-01-02

PRE

DOI：10.1021/am5075216

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摘要

En 中文

We propose a novel method to obtain versatile droplets arrays on a regional hydrophilic chip that is fabricated by PDMS soft lithography and regional plasma treatment. It enables rapid liquid dispensation and droplets array formation just making the chip surface in contact with solution. By combining this chip with a special Christmas Tree structure, the droplets array with concentrations in gradient is generated. It possesses the greatly improved performance of convenience and versatility in bioscreening and biosensing. For example, high throughput condition screening of toxic tests of CdSe quantum dots on HL-60 cells are conducted and cell death rates are successfully counted quickly and efficiently. Furthermore, a rapid biosensing approach for cancer biomarkers carcinoma embryonic antigen (CEA) is developed via magnetic beads (MBs)-based sandwich immunoassay methods.

Keyword:

droplets array

liquid dispensation

rapid analysis

surface wettability

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期刊

ACS Applied Materials and Interfaces

IF:

8.2

论文数:

6.1W

被引数:

38.7W

机构

nanjing university

学者数:

7.8W

论文数: 5.6W

被引数: 87

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