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Vertebrate endoderm development

delete2026-05-01
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PRE
AI
W
Weatherbee, Bailey A. T.
S
Scott A. Rankin
A
Aaron M. Zorn *
DOI：10.1242/dev.205164delete
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摘要

摘要

En 中文
内胚层形成胚胎肠管的最内层。它分化为许多内部器官的上皮和腺体成分，包括消化系统和呼吸系统的器官。内胚层器官具有营养吸收、呼吸、解毒和内分泌调节等基本生理过程。在过去二十年里，脊椎动物胚胎和人类多能干细胞模型的研究明确了调控内胚层形成、区域化和器官发生机制的原理。这些过程由保守的细胞信号通路驱动，与谱系特异性转录因子协同作用以建立和精炼内胚层细胞身份。内胚层与邻近中胚层之间的相互作用进一步指导组织形态发生和器官特异性分化。这些研究不仅揭示了发育的基本原理，还阐明了先天性疾病的起源，并推动了在体外构建功能性人体组织用于疾病建模和再生医学的努力。
Keyword:
Endoderm development
Vertebrates
Organogenesis
Stem cells

期刊

Development 封面图
Development
IF:
3.6
论文数:
9.8K
被引数:
4.9W

机构

C
Cincinnati Children's Hospital Medical Center
学者数:
1.8K
论文数: 593
被引数: 1.8W
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